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| 1 | 2 | 3 | 4 | T | |
| Indianapolis Colts | 0 | 7 | 0 | 11 | 18 |
| Buffalo Bills | 3 | 6 | 0 | 7 | 16 |
| IND | BUF | |
| 1st Downs | 14 | 21 |
| Total Yards | 265 | 385 |
| Passing | ||
| Yards | 184 | 215 |
| Comp-Att-Int | 16-27-1 | 21-32-0 |
| Yards Per Pass | 6.8 | 6.7 |
| Sacked-Yards Lost | 1-3 | 4-31 |
| Rushing | ||
| Yards | 81 | 170 |
| Attempts | 24 | 33 |
| Average | 3.4 | 5.2 |
| Turnovers | ||
| Interceptions | 1 | 0 |
| Fumbles-Lost | 0-0 | 1-0 |
| Punting | ||
| Punts | 5 | 5 |
| Yards | 237 | 193 |
| Yards Per Punt | 47.4 | 38.6 |
| Penalties | ||
| Penalties | 3 | 8 |
| Yards | 20 | 60 |
| Possession | ||
| Time of Possession | 24:01 | 35:59 |
| PASSING | |||||||||||
| Indianapolis | CMP | ATT | PCT | YDS | LNG | YPA | TD | INT | SCK | LOSS | RAT |
| Peyton Manning | 16 | 27 | 59.3 | 187 | 30 | 6.93 | 2 | 1 | 1 | 3 | 89.6 |
| Buffalo | CMP | ATT | PCT | YDS | LNG | YPA | TD | INT | SCK | LOSS | RAT |
| Rob Johnson | 21 | 32 | 65.6 | 246 | 40t | 7.69 | 1 | 0 | 4 | 31 | 99.2 |
| RUSHING | |||||||||||
| Indianapolis | ATT | YDS | AVG | LNG | TD | ||||||
| Edgerrin James | 19 | 60 | 3.2 | 13 | 0 | ||||||
| Peyton Manning | 5 | 21 | 4.2 | 8 | 0 | ||||||
| Buffalo | ATT | YDS | AVG | LNG | TD | ||||||
| Jonathan Linton | 13 | 58 | 4.5 | 12 | 0 | ||||||
| Shawn Bryson | 11 | 43 | 3.9 | 11 | 0 | ||||||
| Rob Johnson | 5 | 41 | 8.2 | 14 | 0 | ||||||
| Sammy Morris | 4 | 28 | 7.0 | 15 | 0 | ||||||
| RECEIVING | |||||||||||
| Indianapolis | REC | YDS | AVG | LNG | TD | ||||||
| Marvin Harrison | 3 | 45 | 15.0 | 27 | 1 | ||||||
| Edgerrin James | 4 | 43 | 10.8 | 13 | 0 | ||||||
| Ken Dilger | 2 | 36 | 18.0 | 30 | 0 | ||||||
| Jerome Pathon | 3 | 28 | 9.3 | 13 | 0 | ||||||
| Marcus Pollard | 3 | 25 | 8.3 | 13 | 0 | ||||||
| Terrence Wilkins | 1 | 10 | 10.0 | 10t | 1 | ||||||
| Buffalo | REC | YDS | AVG | LNG | TD | ||||||
| Eric Moulds | 9 | 112 | 12.4 | 40t | 1 | ||||||
| Jeremy Mcdaniel | 3 | 73 | 24.3 | 32 | 0 | ||||||
| Sammy Morris | 4 | 44 | 11.0 | 20 | 0 | ||||||
| Peerless Price | 1 | 14 | 14.0 | 14 | 0 | ||||||
| Bobby Collier | 1 | 5 | 5.0 | 5 | 0 | ||||||
| Jonathan Linton | 1 | 3 | 3.0 | 3 | 0 | ||||||
| Shawn Bryson | 1 | 1 | 1.0 | 1 | 0 | ||||||
| Rob Johnson | 1 | -6 | -6.0 | -6 | 0 | ||||||
| KICK/PUNT RETURNS | |||||||||||
| Indianapolis | KR | YDS | AVG | LNG | TD | PR | YDS | AVG | LNG | TD | |
| Terrence Wilkins | 0 | 0 | 0.0 | 0 | 0 | 1 | 14 | 14.0 | 14 | 0 | |
| David Macklin | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 | |
| Jerome Pathon | 4 | 54 | 13.5 | 18 | 0 | 0 | 0 | 0.0 | 0 | 0 | |
| Buffalo | KR | YDS | AVG | LNG | TD | PR | YDS | AVG | LNG | TD | |
| Chris Watson | 2 | 39 | 19.5 | 24 | 0 | 2 | 23 | 11.5 | 14 | 0 | |
| PUNTING | |||||||||||
| Indianapolis | NUM | YDS | AVG | LNG | TB | IN20 | BLK | ||||
| Hunter Smith | 5 | 237 | 47.4 | 64 | 2 | 0 | 0 | ||||
| Buffalo | NUM | YDS | AVG | LNG | TB | IN20 | BLK | ||||
| Chris Mohr | 5 | 193 | 38.6 | 52 | 2 | 1 | 0 | ||||
| DEFENSE | |||||||||||
| Indianapolis | SK | YDS | INT | YDS | LNG | TD | |||||
| Bernard Holsey | 1 | 1 | 0 | 0 | 0 | 0 | |||||
| Dwight Hollier | 1 | 7 | 0 | 0 | 0 | 0 | |||||
| Chad Bratzke | 2 | 23 | 0 | 0 | 0 | 0 | |||||
| Buffalo | SK | YDS | INT | YDS | LNG | TD | |||||
| Antoine Winfield | 0 | 0 | 1 | 8 | 8 | 0 | |||||
| Keith Newman | 1 | 3 | 0 | 0 | 0 | 0 | |||||
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