Record: 13 - 3 (pythagorean: 11 - 5, .739)
Coaching: Marv Levy 13 - 3 (playoffs:2 - 1)
1991 Pro Bowl Players: QB - Jim Kelly RB - Thurman Thomas WR - Steve Tasker WR - James Lofton WR - Andre Reed G - Jim Ritcher LB - Darryl Talley LB - Cornelius Bennett
| Round - Pick (Overall Pick) 1-26 (26) - Henry Jones, Illinois, DB 2-27 (54) - Phil Hansen, North Dakota State, DE 3-27 (82) - Darryl Wren, Pittsburg State (KS), DB 5-27 (138) - Shawn Wilbourn, Long Beach State, DB 6-27 (166) - Millard Hamilton, Clark, WR 7-27 (194) - Amir Rasul, Florida A&M, RB 8-27 (222) - Brad Lamb, Anderson, WR 9-26 (249) - Mark Maddox, Northern Michigan, LB 10-27 (277) - Tony DeLorenzo, New Mexico State, G 11-27 (305) - Dean Kirkland, Washington, G 12-27 (333) - Stephen Clark, Texas, TE
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