Record: 11 - 5 (pythagorean: 10 - 6, .668)
Coaching: Don Coryell 11 - 5 (playoffs:1 - 1)
1980 Pro Bowl Players: QB - Dan Fouts WR - John Jefferson WR - Charlie Joiner G - Doug Wilkerson DE - Fred Dean DT - Louie Kelcher DT - Gary Johnson
| Round - Pick (Overall Pick) 4-18 (101) - Ed Luther, San Jose State, QB 4-25 (108) - Bob Gregor, Washington State, DB 6-13 (151) - LaRue Harrington, Norfolk State, RB 6-25 (163) - Wayne Hamilton, Alabama, LB 7-10 (175) - Chuck Loewen, South Dakota State, G 7-26 (191) - Stuart Dodds, Montana State, P 8-26 (219) - Curtis Sirmones, North Alabama, RB 9-0 (0) - Billy Mullins, USC, WR (supplemental draft) 9-26 (247) - Steve Whitman, Alabama, RB 11-26 (303) - John Singleton, Texas-El Paso, DE 12-26 (331) - Harry Price, McNeese State, WR
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