Record: 10 - 6 (pythagorean: 10 - 6, .641)
Coaching: Don Coryell 10 - 6 (playoffs:1 - 1)
1981 Pro Bowl Players: QB - Dan Fouts RB - Chuck Muncie G - Doug Wilkerson DE - Fred Dean DT - Gary Johnson
| Round - Pick (Overall Pick) 1-24 (24) - James Brooks, Auburn, RB 3-21 (77) - Irvin Phillips, Arkansas Tech, DB 4-20 (103) - Amos Lawrence, North Carolina, RB 4-24 (107) - Eric Sievers, Maryland, TE 5-20 (131) - Keith Ferguson, Ohio State, LB 6-3 (141) - Andy Gissinger, Syracuse, T 6-24 (162) - Bobby Duckworth, Arkansas, WR 7-23 (189) - Pete Holohan, Notre Dame, TE 10-20 (268) - Robert Parham, Grambling, RB 11-4 (280) - Matt Petrzelka, Iowa, T 11-24 (300) - Carlos Bradley, Wake Forest, LB 12-23 (327) - Stacy Charles, Bethune-Cookman, WR
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