Record: 13 - 3 (pythagorean: 11 - 5, .734)
Coaching: Bill Walsh 13 - 3 (playoffs:3 - 0)
1981 Pro Bowl Players: QB - Joe Montana WR - Dwight Clark OG - Randy Cross DE - Fred Dean CB - Ronnie Lott S - Dwight Hicks
| Round - Pick (Overall Pick) 1-8 (8) - Ronnie Lott, USC, DB 2-8 (36) - John Harty, Iowa, DT 2-12 (40) - Eric Wright, Missouri, DB 3-9 (65) - Carlton Williamson, Pittsburgh, DB 5-10 (121) - Lynn Thomas, Pittsburgh, DB 5-11 (122) - Arrington Jones, Winston-Salem State, RB 6-9 (147) - Pete Kugler, Penn State, DT 8-10 (203) - Garry White, Minnesota, RB 11-10 (286) - Rob DeBose, UCLA, TE 12-9 (313) - Major Ogilvie, Alabama, RB 12-18 (322) - Joe Adams, Tennessee State, QB
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